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Alessandro Camponeschi
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Avd för reumatologi och inflammationsforskningOm Alessandro Camponeschi
Vi studerar B-cellsbaserade cancersjukdomar, inklusive leukemier och lymfom, med fokus på två huvudsakliga områden. För det första undersöker vi hur tumörmikromiljön främjar immunologisk undvikning och terapirestistens, särskilt genom immunhämmande signalvägar som involverar extracellulärt adenosin. För det andra studerar vi B-cellsreceptorsignalering (BCR) och dess roll i att upprätthålla överlevnad hos maligna B-celler och driva sjukdomsprogression. Inom detta område är vi särskilt intresserade av hur proteiner som CD38 reglerar dessa processer och bidrar till behandlingsresistens.
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Transitional and CD21PD-1 B cells are associated with remission in early rheumatoid
arthritis
Sarah McGrath, Boel Sundbeck, Katrin Thorarinsdottir, Charlotte A Jonsson, Alessandro Camponeschi, Monica Leu Agelii, Anna-Karin H. Ekwall, Merete Lund Hetland, Mikkel Ostergaard, Till Uhlig, Michael Nurmohamed, Jon Lampa, Dan Nordstrom, Kim Horslev-Petersen, Bjorn Gudbjornsson, Gerdur Grondal, Ronald van Vollenhoven, Anna Rudin, Inga-Lill Mårtensson, Inger Gjertsson
BMC RHEUMATOLOGY - 2025 -
Testosterone exacerbates neutrophilia and cardiac injury in myocardial infarction via actions in bone
marrow.
Elin Svedlund Eriksson, Marta Lantero Rodriguez, Bente Halvorsen, Inger Johansson, Anna K. F. Mårtensson, Anna S K Wilhelmson, Camilla Huse, Thor Ueland, Pål Aukrust, Kaspar Broch, Lars Gullestad, Brage Høyem Amundsen, Geir Øystein Andersen, Mikael C I Karlsson, Malin Hagberg Thulin, Alessandro Camponeschi, Dana Trompet, Ola Hammarsten, Björn Redfors, Jan Borén, Elmir Omerovic, Malin Levin, Andrei S. Chagin, Tuva B Dahl, Åsa Tivesten
Nature Communications - 2025 -
Design and application of a fluorescent probe for imaging of endogenous Bruton's tyrosine kinase with preserved enzymatic
activity
Anna Paraskevi Valaka, Hampus Nyström, Liliana Håversen, Carlos Benitez-Martin, Clara Schäfer, Woo Suk Jang, Alessandro Camponeschi, Joakim Andreasson, Jan Borén, Morten Grötli
RSC CHEMICAL BIOLOGY - 2025 -
Targeting CD38 with monoclonal antibodies disrupts key survival pathways in paediatric Burkitt's lymphoma malignant B
cells
Kathrin Klaesener, Nadja Herrmann, Liliana Håversen, Timothy Sundell, Martina Sundqvist, Christina Lundqvist, Paul Manna, Charlotte A Jonsson, Marcella Visentini, Diana Ljung Sass, Sarah McGrath, Kristoffer Grimstad, Alaitz Aranburu, Karin Mellgren, Linda Fogelstrand, Huamei Forsman, Olov Ekwall, Jan Borén, Inger Gjertsson, Michael Reth, Inga-Lill Mårtensson, Alessandro Camponeschi
Clinical & translational immunology - 2024 -
A landscape of X-inactivation during human T cell
development.
Björn Gylemo, Maike Bensberg, Viktoria Hennings, Christina Lundqvist, Alessandro Camponeschi, Dóra Goldmann, Huan Zhang, Aida Selimović-Pašić, Antonio Lentini, Olov Ekwall, Colm E Nestor
Nature communications - 2024 -
Correlation of Professional Antigen-Presenting Tbet+CD11c+ B Cells With Bone Destruction in Untreated Rheumatoid
Arthritis
Sarah McGrath, Kristoffer Grimstad, Katrin Thorarinsdottir, Kristina Forslind, Daniel Glinatsi, Monica Leu Agelii, Alaitz Aranburu, Timothy Sundell, Charlotte A Jonsson, Alessandro Camponeschi, Anna-Karin Hultgård Ekwall, Andreas Tilevik, Inger Gjertsson, Inga-Lill Mårtensson
ARTHRITIS & RHEUMATOLOGY - 2024 -
Dual stimulation by autoantigen and CpG fosters the proliferation of exhausted rheumatoid factor-specific CD21(low) B cells in hepatitis C virus-cured mixed
cryoglobulinemia
M. Del Padre, R. Marrapodi, Y. A. Minafo, E. P. Mortari, G. Radicchio, C. Bocci, L. Gragnani, Alessandro Camponeschi, S. Colantuono, L. Stefanini, S. Basili, R. Carsetti, M. Fiorilli, M. Casato, M. Visentini
FRONTIERS IN IMMUNOLOGY - 2023 -
Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional
Extensions
Muhammad Nawaz, Sepideh Heydarkhan-Hagvall, Benyapa Tangruksa, Hernán González-King Garibotti, Yujia Jing, Maugeri Marco, Franziska Kohl, Leif Hultin, Azadeh Reyahi, Alessandro Camponeschi, Bengt Kull, Jonas Christoffersson, Ola Grimsholm, Karin Jennbacken, Martina Sundqvist, John Wiseman, Abdel Wahad Bidar, Lennart Lindfors, Jane Synnergren, Hadi Valadi
Advanced Science - 2023 -
Single-cell RNA sequencing analyses: interference by the genes that encode the B-cell and T-cell
receptors
Timothy Sundell, Kristoffer Grimstad, Alessandro Camponeschi, A. Tilevik, Inger Gjertsson, Inga-Lill Mårtensson
Briefings in Functional Genomics - 2023 -
Clonal relationships of memory B cell subsets in autoimmune
mice
Alaitz Aranburu, E. Engstrom, Natalija Gerasimcik, Samuel Alsén, Alessandro Camponeschi, Ulf Yrlid, Ola Grimsholm, Inga-Lill Mårtensson
Frontiers in Immunology - 2023 -
Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B
cells.
Alessandro Camponeschi, Kathrin Kläsener, Timothy Sundell, Christina Lundqvist, Paul T Manna, Negar Ayoubzadeh, Martina Sundqvist, Katrin Thorarinsdottir, Mariele Gatto, Marcella Visentini, Karin Önnheim, Alaitz Aranburu, Huamei Forsman, Olov Ekwall, Linda Fogelstrand, Inger Gjertsson, Michael Reth, Inga-Lill Mårtensson
The Journal of experimental medicine - 2022 -
A close-up on the expanding landscape of CD21(-)/low B cells in
humans
Inger Gjertsson, Sarah McGrath, Kristoffer Grimstad, Charlotte A Jonsson, Alessandro Camponeschi, Katrin Thorarinsdottir, Inga-Lill Mårtensson
Clinical and Experimental Immunology - 2022 -
RAG1 co-expression signature identifies ETV6-RUNX1-like B-cell precursor acute lymphoblastic leukemia in
children
Dongfeng Chen, Alessandro Camponeschi, J. Nordlund, Y. Marincevic-Zuniga, J. Abrahamsson, G. Lönnerholm, Linda Fogelstrand, Inga-Lill Mårtensson
Cancer Medicine - 2021 -
Nicotine Changes the microRNA Profile to Regulate the FOXO Memory Program of CD8(+)T Cells in Rheumatoid
Arthritis
Caroline Wasén, C. Ospelt, Alessandro Camponeschi, Malin Erlandsson, Karin Andersson, Sofia Töyrä Silfverswärd, S. Gay, Maria Bokarewa
Frontiers in Immunology - 2020 -
Rheumatoid factor-producing CD21low anergic clonal B-cells in essential mixed cryoglobulinaemia: a model for autoantigen-driven pathogenesis of infectious and non-infectious
cryoglobulinaemias
M. Del Padre, Y. A. Minafò, R. Marrapodi, G. Radicchio, M. Granata, Alessandro Camponeschi, M. Fiorilli, L. Quartuccio, S. De Vita, M. Casato, S. Colantuono, M. Visentini
Clinical and experimental rheumatology - 2020 -
Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other
cells
Maugeri Marco, Muhammad Nawaz, Alexandros Papadimitriou, Annelie Angerfors, Alessandro Camponeschi, Manli Na, Mikko Hölttä, Pia Skantze, Svante Johansson, Martina Sundqvist, Johnny Lindquist, Tomas Kjellman, Inga-Lill Mårtensson, Tao Jin, Per Sunnerhagen, Sofia Östman, Lennart Lindfors, Hadi Valadi
Nature Communications - 2019 -
Switched CD21-/low B cells with an antigen-presenting phenotype in the infant
thymus.
Christina Lundqvist, Alessandro Camponeschi, Marcella Visentini, Esbjörn Telemo, Olov Ekwall, Inga-Lill Mårtensson
The Journal of allergy and clinical immunology - 2019 -
Dissecting Integrin Expression and Function on Memory B Cells in Mice and Humans in
Autoimmunity.
Alessandro Camponeschi, Natalija Gerasimcik, Ying Wang, Timothy Fredriksson, Dongfeng Chen, Chiara Farroni, Katrin Thorarinsdottir, Louise Sjökvist Ottsjö, Alaitz Aranburu, Susanna Cardell, Rita Carsetti, Inger Gjertsson, Inga-Lill Mårtensson, Ola Grimsholm
Frontiers in immunology - 2019 -
ERG Controls B Cell Development by Promoting Igh V-to-DJ
Recombination
E. Sondergaard, A. Rauch, M. Michaut, N. Rapin, M. Rehn, A. S. Wilhelmson, Alessandro Camponeschi, M. S. Hasemann, F. O. Bagger, J. Jendholm, K. J. Knudsen, S. Mandrup, Inga-Lill Mårtensson, B. T. Porse
Cell Reports - 2019 -
CD21(-/low) B cells associate with joint damage in rheumatoid arthritis
patients
Katrin Thorarinsdottir, Alessandro Camponeschi, Charlotte A Jonsson, Karin Önnheim, Jenny Nilsson, K. Forslind, M. Visentini, Lennart T. H. Jacobsson, Inga-Lill Mårtensson, Inger Gjertsson
Scandinavian Journal of Immunology - 2019 -
CD99 expression is strongly associated with clinical outcome in children with B-cell precursor acute lymphoblastic
leukaemia
Dongfeng Chen, Alessandro Camponeschi, Qingqing Wu, Natalija Gerasimcik, Huiqi Li, Xue Shen, Yujie Tan, Helene Sjögren, Jessica Nordlund, Gudmar Lönnerholm, Jonas Abrahamsson, Linda Fogelstrand, Inga-Lill Mårtensson
British Journal of Haematology - 2019 -
Testosterone is an endogenous regulator of BAFF and splenic B cell
number
Anna S K Wilhelmson, Marta Lantero Rodriguez, Alexandra Stubelius, Per Fogelstrand, Inger Johansson, M. B. Buechler, S. Lianoglou, V. N. Kapoor, Maria E Johansson, Johan Bourghardt Fagman, A. Duhlin, P. Tripathi, Alessandro Camponeschi, B. T. Porse, A. G. Rolink, Hans Nissbrandt, S. J. Turley, Hans Carlsten, Inga-Lill Mårtensson, M. C. I. Karlsson, Åsa Tivesten
Nature Communications - 2018 -
Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: A potential explanation for the increased risk of rheumatoid arthritis in postmenopausal
women
Cecilia Engdahl, A. Bondt, U. Harre, J. Raufer, R. Pfeifle, Alessandro Camponeschi, M. Wuhrer, M. Seeling, Inga-Lill Mårtensson, F. Nimmerjahn, G. Krönke, H. U. Scherer, Helena Forsblad d'Elia, G. Schett
Arthritis Research and Therapy - 2018 -
DEC1/STRA13 is a key negative regulator of activation-induced proliferation of human B cells highly expressed in anergic
cells
Alessandro Camponeschi, L. Todi, C. Cristofoletti, C. Lazzeri, M. Carbonari, M. Mitrevski, R. Marrapodi, M. Del Padre, M. Fiorilli, M. Casato, M. Visentini
Immunology Letters - 2018 -
Age-associated B cells expanded in autoimmune mice are memory cells sharing H-CDR3-selected
repertoires
Alaitz Aranburu, Nina Höök, Natalija Gerasimcik, Bjorn Corleis, Weicheng Ren, Alessandro Camponeschi, Hans Carlsten, Ola Grimsholm, Inga-Lill Mårtensson
European Journal of Immunology - 2018 -
CD27 expression and its association with clinical outcome in children and adults with pro-B acute lymphoblastic
leukemia.
Dongfeng Chen, Natalija Gerasimcik, Alessandro Camponeschi, Y Tan, Q Wu, Siggeir Fannar Brynjólfsson, Junxiong Zheng, Jonas Abrahamsson, J Nordlund, G Lönnerholm, Linda Fogelstrand, Inga-Lill Mårtensson
Blood Cancer Journal - 2017 -
Hepatitis B virus causes mixed cryoglobulinaemia by driving clonal expansion of innate B-cells producing a VH1-69-encoded
antibody.
Marcella Visentini, Simona Pascolini, Milica Mitrevski, Ramona Marrapodi, Martina Del Padre, Laura Todi, Alessandro Camponeschi, Evangelos Axiotis, Maurizio Carlesimo, Adriano De Santis, Massimo Fiorilli, Milvia Casato
Clinical and experimental rheumatology - 2016 -
CD21-/low B cells in human blood are memory
cells
Katrin Thorarinsdottir, Alessandro Camponeschi, Nicola Cavallini, Ola Grimsholm, Lennart T. H. Jacobsson, Inger Gjertsson, Lill Mårtensson-Bopp
Clinical and Experimental Immunology - 2016 -
Intravenous Immunoglobulin and Immunomodulation of B-Cell - in vitro and in vivo
Effects.
Milica Mitrevski, Ramona Marrapodi, Alessandro Camponeschi, Filomena Monica Cavaliere, Cristina Lazzeri, Laura Todi, Marcella Visentini
Frontiers in immunology - 2015 -
Absence of surrogate light chain results in spontaneous autoreactive germinal centres expanding V(H)81X-expressing B
cells
Ola Grimsholm, Weicheng Ren, Angelina I Bernardi, Hai-Xia Chen, Giljun Park, Alessandro Camponeschi, Dongfeng Chen, Berglind Bergmann, Nina Höök, Sofia E M Andersson, Anneli Strömberg, Inger Gjertsson, Susanna Cardell, Ulf Yrlid, A. De Riva, Inga-Lill Mårtensson
Nature Communications - 2015 -
CD21(-/low) B cells: A Snapshot of a Unique B Cell Subset in Health and
Disease
Brynja Kristin Thorarinsdottir, Alessandro Camponeschi, Inger Gjertsson, Inga-Lill Mårtensson
Scandinavian Journal of Immunology - 2015 -
Intravenous immunoglobulin replacement therapy in common variable immunodeficiency induces B cell depletion through differentiation into apoptosis-prone CD21(low) B
cells.
Milica Mitrevski, Ramona Marrapodi, Alessandro Camponeschi, Cristina Lazzeri, Laura Todi, Isabella Quinti, Massimo Fiorilli, Marcella Visentini
Immunologic research - 2014 -
Dysregulated extracellular signal-regulated kinase signaling associated with impaired B-cell receptor endocytosis in patients with common variable
immunodeficiency.
Marcella Visentini, Ramona Marrapodi, Valentina Conti, Milica Mitrevski, Alessandro Camponeschi, Cristina Lazzeri, Maurizio Carbonari, Angela Catizone, Isabella Quinti, Massimo Fiorilli
The Journal of allergy and clinical immunology - 2014